KOMATSU Norio, M.D., Ph.D.
Department of Development of Therapies Against MPN
Short Biography
| 1975-1981 | M.D. Niigata University |
| 1981-1983 | Post-graduate Student, Department of Hematology, Jichi Medical University |
| 1983-1992 | Clinical Research Fellow, Department of Hematology, Jichi Medical University |
| 1990-1991 | Research Fellow, New York Blood Center |
| 1992-2000 | Assistant Professor, Department of Hematology, Jichi Medical University |
| 2000-2004 | Associate Professor, Department of Hematology, Jichi Medical University |
| 2004-2009 | Professor and Chairman, Department of Hematology / Oncology, Yamanashi University |
| 2009-2021 | Professor and Chairman, Department of Hematology, Juntendo University Faculty of Medicine |
| 2021-Present | Project Professor, Development of Therapies against MPN, Advanced Hematology, Graduate School of Medicine, Juntendo University, Department of Hematology, Juntendo University Faculty of Medicine |
Keywords
- Myeloproliferative Neoplasms
- Calreticulin (CALR)
- JAK2
- Immunotherapy
- Antibody Development
Main Research Topics and Interests
- Understanding the molecular mechanism of MPN development by mutant CALR
- Understanding the signal transduction induced by MPN-related mutant proteins
- Development of diagnostic tools for hematological malignancies
- Development of novel therapeutic strategies for hematological malignancies
Publications (in English)
- Original Articles: 308
- Review Articles: 21
- Books: 1
- h-Index: 40
- Sum of Times Cited: 6,179 (Web of Science)
Recent Main Publications
- Yokomizo T, Ideue T, Morino-Koga S, Tham CY, Sato T, Takeda N, Kubota Y, Kurokawa M, Komatsu N, Ogawa M, Araki K, Osato M, Suda T. Independent origins of fetal liver haematopoietic stem and progenitor cells. Nature. 2022 Sep;609(7928):779-784.
- Pecquet C, Papadopoulos N, Balligand T, Chachoua I, Tisserand A, Vertenoeil G, Nédélec A, Vertommen D, Roy A, Marty C, Nivarthi H, Defour JP, El-Khoury M, Hug E, Majoros A, Xu E, Zagrijtschuk O, Fertig TE, Marta DS, Gisslinger H, Gisslinger B, Schalling M, Casetti IC, Rumi E, Pietra D, Cavalloni C, Arcaini L, Cazzola M, Komatsu N, Kihara Y, Sunami Y, Edahiro Y, Araki M, Lesyk R, Buxhofer-Ausch V, Heibl S, Pasquier F, Plo I, Vainchenker W, Kralovics R, Constantinescu SN. Secreted Mutant Calreticulins As Rogue Cytokines in Myeloproliferative Neoplasms. Blood. 2022 Nov 10:blood.2022016846.
- Watari H, Kageyama H, Masubuchi N, Nakajima H, Onodera K, Focia PJ, Oshiro T, Matsui T, Kodera Y, Ogawa T, Yokoyama T, Hirayama M, Hori K, Freymann DM, Imai M, Komatsu N, Araki M, Tanaka Y, Sakai R. A marine sponge-derived lectin reveals hidden pathway for thrombopoietin receptor activation. Nat Commun. 2022 Nov 25;13(1):7262
- Furuya C, Hashimoto Y, Morishita S, Inano T, Ochiai T, Shirane S, Edahiro Y, Araki M, Ando M, Komatsu N. Reevaluation of cardiovascular risk factors for thrombotic events in 580 Japanese patients with essential thrombocythemia. J Thromb Thrombolysis. 2022; 10.1007/s11239-022-02751-0
- Baba T, Hashimoto Y, Yasuda H, Araki M, Edahiro Y, Morishita S, Ochiai T, Shirane S, Ando J, Komatsu N. Validation and reliability of current guidelines for the treatment of essential thrombocythemia under real-world clinical settings in Japan. Hematology. 2022 Dec;27(1):157-166
- Liu C, Imai M, Edahiro Y, Mano S, Takei H, Nudejima M, Kurose A, Morishita S, Ando M, Tsuneda S, Araki M, Komatsu N. Establishment of isogenic induced pluripotent stem cells with or without pathogenic mutation for understanding the pathogenesis of myeloproliferative neoplasms. Exp Hematol. 2022; 10.1016/j.exphem.2022.11.005
- Edahiro Y, Ito T, Gotoh A, Nakamae M, Kimura F, Koike M, Kirito K, Wada H, Usuki K, Tanaka T, Mori T, Wakita S, Saito TI, Kada A, Saito AM, Shimoda K, Sugimoto Y, Kurokawa T, Tomita A, Hashimoto Y, Akashi K, Matsumura I, Takenaka K, Komatsu N. Clinical characteristics of Japanese patients with polycythemia vera: results of the JSH-MPN-R18 study. Int J Hematol. 2022 Nov;116(5):696-711.
- Morishita S, Hashimoto Y, Furuya C, Edahiro Y, Ochiai T, Shirane S, Inano T, Yasuda H, Ando M, Araki M, Komatsu N. Non-driver gene mutation analysis in a large cohort of polycythemia vera and essential thrombocythemia. Eur J Haematol. 2022; 110(2):131-136.
- De Marchi F, Okuda M, Morishita S, Imai M, Baba T, Horino M, Mori Y, Furuya C, Ogata S, Yang Y, Ando J, Ando M, Araki M, Komatsu N. Clinical and biological relevance of CREB3L1 in Philadelphia chromosome-negative myeloproliferative neoplasms. Leuk Res. 2022 May 31;119:106883.
- Mori Y, Araki M, Morishita S, Imai M, Edahiro Y, Ito M, Ochiai T, Shirane S, Hashimoto Y, Yasuda H, Ando J, Ando M, Komatsu N. Clinical features of acquired erythrocytosis: Low levels of serum erythropoietin in a subset of non-neoplastic erythrocytosis patients. Cancer Med. 2022 Jul 1; 10.1002/cam4.4958Muto S, Kamiyama Y, Ide H, Okada H, Saito K, Nishio K, Tokiwa S, Kaminaga T, Furui S, Horie S: Real-time MRI of Orthotopic ileal neobladder voiding: preliminary findings. European Urology, 2008; 53: 363-369.
- More
Award and Honors
- The 56th (FY2019) Erwin von Bälz Prize（Second Prize）
- The 9th (FY2020) Japanese Society of Hematology Award
Link
Department of Therapies Against MPNDepartment of Advanced Hematology