SAKURAI Takashi, M.D., Ph.D.
Department of Cellular and Molecular Pharmacology
Short Biography
| 1990 | Research Associate, Department of Pharmacology, The University of Tokyo Faculty of Medicine |
| 1997 | Visiting Scholar, Department of Molecular and Cellular Biology, Harvard University (Prof. Daniel G Jay's Lab) |
| 1998 | Postdoctoral Fellow, Department of Physiology, Tufts University School of Medicine (Prof. Daniel G Jay's Lab) |
| 2000 | Research Scientist, RIKEN Brain Science Institute |
| 2006-Present | Professor, Department of Pharmacology, Juntendo University Faculty of Medicine |
Keywords
- Alzheimer's Disease
- Beta-amyloid
- Membrane Microdomain
- Cholesterol
- Fluorophore-assisted Light Inactivation (FALI)
Main Research Topics and Interests
- Microdomain-dependent regulatory mechanism of amyloid precursor protein (APP) processing
- Physiological substrates and functions of beta-secretase (BACE1) in neurons
- Functional proteomic screen using fluorophore-assisted light inactivation (FALI)
Publications (in English)
- Original Articles: 77
- Review Articles: 1
- Books: 2
- h-index: 28 (Scopus)
- Sum of Times Cited: 3,253 (Scopus)
Recent Main Publications
- Yamazawa T, Kobayashi T, Kurebayashi N, Konishi M, Noguchi S, Inoue T, Inoue YU, Nishino I, Mori S, Iinuma H, Manaka N, Kagechika H, Uryash A, Adams J, Lopez JR, Liu X, Diggle C, Allen PD, Kakizawa S, Ikeda K, Lin B, Ikemi Y, Nunomura K, Nakagawa S, Sakurai T, Murayama T. A novel RyR1-selective inhibitor prevents and rescues sudden death in mouse models of malignant hyperthermia and heat stroke. Nat Commun 12(1):4293, 2021. doi: 10.1038/s41467-021-24644-1.
- Sakairi H, Kamikubo Y, Abe M, Ikeda K, Ichiki A, Tabata T, Kano M, Sakurai T.: G Protein-Coupled Glutamate and GABA Receptors Form Complexes and Mutually Modulate Their Signals. ACS Chem Neurosci, 11(4):567-578, 2020. doi: 10.1021/acschemneuro.9b00599.
- Takasugi N, Araya R, Kamikubo Y, Kaneshiro N, Imaoka R, Jin H, Kashiyama T, Hashimoto Y, Kurosawa M, Uehara T, Nukina N, Sakurai T.: TMEM30A is a candidate interacting partner for the β-carboxyl-terminal fragment of amyloid-β precursor protein in endosomes. PLoS ONE 13(8): e0200988, 2018. doi.org/10.1371/journal.pone.0200988.
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