Yamashiro Yuichiro

YAMASHIRO Yuichiro, M.D., Ph.D.

Short Biography

Keywords

• Intestinal microbiota
• Probiotics
• Long chain polyunsaturated fatty acids (LCPUFA)
• Breast feeding
• Obesity & metabolic syndrome
• Kawasaki disease

Main Research Topics and Interests

• Intestinal microbiota in relation to health and disease of the host
• Roles of intestinal dysbiosis in metabolic syndrome, in non-communicable diseases
• Roles of probiotics for clinical management of obesity and obesity related diseases
• Etiological study of Kawasaki disease in relation to small intestinal bacteria
• Nutritional treatment of Biliary atresia patients with post Kasai operation, based on the microbiota composition

Publications (in English) (2005-2021)

• Original Articles: 78
• Review Articles: 24
• Books: 3
• h-Index: 29 (Web of Science)
• Sum of Times Cited: 2,199 (Web of Science)

Recent Main Publications

• Kanazawa A, Aida M, Yoshida Y, Kaga H, Katahira T, Suzuki L, Tamaki S, Sato J, Goto H, Azuma K, Shimizu T, Takahashi T, Yamashiro Y, Watada H. Effects of Synbiotic Supplementation on Chronic Inflammation and the Gut Microbiota in Obese Patients with Type 2 Diabetes Mellitus: A Randomized Controlled Study. Nutrients. 2021; 13(2): 558.
• Hattori N, Yamashiro Y. The Gut-Brain Axis. Ann Nutr Metab. 2021: 1-3.
• Yamashiro Y. Effects of Enteral Administration of Bifidobacterium Breve on Dysbiosis Infants and Children: A Review. Br J Gastroenterol. 2020; 2(3): 185-189.
• Yamashiro Y. Effects of Enteral Administration of Lactobacillus Casei Strain Shirotaon Healthy Children, Dysbiosis in Obese Children, and the Elderly. Br J Gastroenterol. 2020; 2(3): 189-193.
• Kurita N, Yamashiro K, Kuroki T, Tanaka R, Urabe T, Ueno Y, Miyamoto N, Takanashi M, Shimura H, Inaba T, Yamashiro Y, Nomoto K, Matsumoto S, Takahashi T, Tsuji H, Asahara T, Hattori N. Metabolic endotoxemia promotes neuroinflammation after focal cerebral ischemia. J Cereb Blood Flow Metab. 2020: 271678X19899577.
• Kubo Y, Fukuoka H, Kawabata T, Shoji K, Mori C, Sakurai K, Nishikawa M, Ohkubo T, Oshida K, Yanagisawa N, Yamashiro Y. Distribution of 5-Methyltetrahydrofolate and Folic Acid Levels in Maternal and Cord Blood Serum: Longitudinal Evaluation of Japanese Pregnant Women. Nutrients. 2020; 12(6): E1633.
• Zhang J, Cameron D, Quak SH, Kadim M, Mohan N, Ryoo E, Sandhu B, Yamashiro Y, Guarino A, Hoekstra H. Rates and Determinants of Antibiotics and Probiotics Prescription to Children in Asia-Pacific Countries. Benef Microbes. 2020; 1-10.
• Oshiro T, Nagata S, Wang C, Takahashi T, Tsuji H, Asahara T, Nomoto K, Takei H, Nittono H, Yamashiro Y. Bifidobacterium Supplementation of Colostrum and Breast Milk Enhances Weight Gain and Metabolic Responses Associated with Microbiota Establishment in Very-Preterm Infants. Biomed Hub. 2019; 4(3): 1-10.
• Tamaki S, Kanazawa A, Sato J, Tamura Y, Asahara T, Takahashi T, Matsumoto S, Yamashiro Y, Watada H. Clinical factors associated with bacterial translocation in Japanese patients with type 2 diabetes: A retrospective study. PLoS One. 2019; 14(9): e0222598.
• Hojo M, Asahara T, Nagahara A, Takeda T, Matsumoto K, Ueyama H, Matsumoto K, Asaoka D, Takahashi T, Nomoto K, Yamashiro Y, Watanabe S. Gut Microbiota Composition Before and After Use of Proton Pump Inhibitors. Dig Dis Sci. 2018; 63(11): 2940-2949.
• Nagpal R, Yamashiro Y. Gut Microbiota Composition in Healthy Japanese Infants and Young Adults Born by C-Section. Ann Nutr Metab. 2018; 73(suppl 3): 4-11.
• Nagata S, Chiba Y, Wang C, Yamashiro Y. The effects of the Lactobacillus casei strain on obesity in children: a pilot study. Benef Microbes. 2017; 8(4): 535-543.
• Yamashiro K, Tanaka R, Urabe T, Ueno Y, Yamashiro Y, Nomoto K, Takahashi T, Tsuji H, Asahara T, Hattori N. Gut dysbiosis is associated with metabolism and systemic inflammation in patients with ischemic stroke. PLoS One. 2017; 12(2): e0171521.
• Suzuki Y, Ikeda K, Sakuma K, Kawai S, Sawaki K, Asahara T, Takahashi T, Tsuji H, Nomoto K, Nagpal R, Wang C, Nagata S, Yamashiro Y. Association between Yogurt Consumption and Intestinal Microbiota in Healthy Young Adults Differs by Host Gender. Front Microbiol. 2017; 8: 847.
• Sato J, Kanazawa A, Azuma K, Ikeda F, Goto H, Komiya K, Kanno R, Tamura Y, Asahara, Takahashi T, Nomoto K, Yamashiro Y, Watada H. Probiotic reduces bacterial translocation in type 2 diabetes mellitus: A randomised controlled study. Sci Rep. 2017; 7(1): 12115.
• Nagpal R, Tsuji H, Takahashi T, Nomoto K, Kawashima K, Nagata S, Yamashiro Y. Gut dysbiosis following C-section instigates higher colonization of toxigenic Clostridium perfringens in infants. Beneficial Microbes. 2017; 8(3): 353-365.
• Nagpal R, Kurakawa T, Tsuji H, Takahashi T, Kawashima K, Nagata S, Nomoto K, Yamashiro Y. Evolution of gut Bifidobacterium population in healthy Japanese infants over the first three years of life: a quantitative assessment. Scientific Reports. 2017; 7(1): 10097.
• Nagpal R, Tsuji H, Takahashi T, Nomoto K, Kawashima K, Nagata S, Yamashiro Y. Ontogenesis of the gut microbiota composition in healthy, full-term, vaginally-born and breast-fed infants over the first 3 years of life: a quantitative bird’s-eye view. Front Microbiol. 2017; 8: 1388.
• Nagpal R, Tsuji H, Takahashi T, Kawashima K, Nagata S, Nomoto K, Yamashiro Y. Sensitive Quantitative Analysis of the Meconium Bacterial Microbiota in Healthy Term Infants Born Vaginally or by Cesarean Section. Front Microbiol. 2016; 7: 1997.
• Okazaki T, Asahara T, Yamataka A, Ogasawara Y, Lane J G, Nomoto K, Nagata S, Yamashiro Y. Intestinal microbiota in pediatric surgical cases administered Bifidobacterium breve: a randomized controlled trial. J Pediatr Gastroenterol Nutr. 2016; 63(1): 46-50.
• Nagata S, Asahara T, Wang C, Suyama Y, Chonan O, Takano K, Daibo M, Takahashi T, Nomoto K, Yamashiro Y. Effectiveness of Lactobacillus beverages for controlling infections in facilities for the elderly: a randomized placebo-controlled double-blind trial. Ann Nutr Metab. 2016; 68(1): 51-9.
• Nagpal R, Ogata K, Tsuji H, Matsuda K, Takahashi T, Nomoto K, Suzuki Y, Kawashima K, Nagata S, Yamashiro Y. Sensitive quantification of Clostridium perfringens in human feces by quantitative real-time PCR targeting alpha-toxin and enterotoxin genes. BMC Microbiology, 2015;15:219.
• Wang C, Nagata S, Asahara T, Yuki N, Matsuda K, Tsuji H, Takahashi T, Nomoto K, Yamashiro Y. Intestinal Microbiota Profiles of Healthy Pre-School and School-Age Children and Effects of Probiotic Supplementation. Ann Nutr Metab, 2015;67(4):257-66.
• Nagpal R, , Yamashiro Y, Izumi Y. The Two-way Association of Periodontal Infection and Systemic Disorders: An Overview. Mediators of Inflammation 2015;2015:793898.
• Yamashiro Y. Metabolic disease: obesity and malnutrition and intestinal microbiota. Journal of Pediatric Biochemistry 2015;05(02):65-70.
• Nagpal R, Yamashiro Y. Early-life gut microbial composition. Journal of Pediatric Biochemistry 2015;05(02):41-50.
• Sato J, Kanazawa A, Ikeda F, Yoshihara T, Goto H, Abe H, Komiya K, Kawaguchi M, Shimizu T, Ogihara T, Tamura Y, Sakurai Y, Yamamoto R, Mita T, Fujitani Y, Fukuda H, Nomoto K, Takahashi T, Asahara T, Hirose T, Nagata S, Yamashiro Y, Watada H. Gut dysbiosis and detection of "live gut bacteria" in blood of Japanese patients with type 2 diabetes. Diabetes Care, 2014; 37(8): 2343-50.
• Koletzko B, Boey CMC, Campoy C, Carlson ES, Chang N, Guillermo-Tuazon MA, Joshi S, Christine Prell, Quak HS, Sjarif RD, Su Y, Supapannachart S, Yamashiro Y, Osendarp JMS. Current Information and Asian Perspectives on Long-Chain Polyunsaturated Fatty Acids in Pregnancy, Lactation, and Infancy: Systematic Review and Practice Recommendations from an Early Nutrition Academy Workshop. Ann Nutr Metab, 2014;65:49–80.
• Rajkumar Hemalatha, Manoj Kumar, Ashok K. Yadav, Sudarshan R, Varikuti, Ravinder Nagpal, Yuichiro Yamashiro, Francesco Marotta. Potential of Probiotics as a Versatile Remedy for Women's Urogental Health: An Optimistic Perspective. International Journal of Probiotics & Prebiotics. 2014; 1-2: 1-16.
• Matsuda K, Tsuji H, Asahara T, Takahashi T, Kubota H, Nagata S, Yamashiro Y, Nomoto K. Sensitive Quanification of Clostridium difficile by Reverse Transcription-Quantitative PCR(RT-qPCR) Targeting rRNA Molecules. Applied and Environmental Microbiology, 2012;78(15):5111-5118.
• Rahman S Md, Nagata S, Matsuda K, Tsuji H, Ogata K, Ozaki S, Kawashima K, Nomoto K, Yamashiro Y. Molecular biological studies of the origin of neonatal fecal Bifidobacterium and Lactobacillus in neonatal feces. International Journal of Probiotics & Prebiotics, 2012;7:91-98.
• Tsuji H, Oozeer R, Matsuda K, Matsuki T, Ohta T, Nomoto K, Tanaka R, Kawashima M, Kawashima K, Nagata S, Yamashiro Y. Molecular monitoring of the development of intestinal microbiota in Japanese infants. Beneficial Microbes, 2012;3:113-125.
• Nagata S, Asahara T, Ohta T, Yamada T, Kondo S, Bian L, Wang C, Yamashiro Y, Nomoto K. Effect of the continuous intake of probiotic fermented milk containing Lactobacillus casei strain Shirota on fever in a mass outbreak of norovirus gastroenteritis and the fecal microflora in a health service facility for the aged. British Journal of Nutrition, 2011;106:549-556.
• Nagata S, Yamashiro Y, Fujimori M, Chiba Y, Ohtsuka Y, Shimizu T. Antimicrobial therapy using sulfamethoxazole trimethoprim for Kawasaki disease patients unresponsive to intravenous immunoglobulin. Open Journal of Pediatrics, 2011;1:27-29.
• Bian L, Nagata S, Asahara T, Rahman S, Ohta T, Yuki K, Wang C, Takano K, Daibo M, Nomoto K, Yamashiro Y. Effects of the continuous intake of probiotic fermented milk that contains Lactobacillus casei strain Shirota on the risk management of long-term inpatients at health service facilities for the elderly. International Journal of Probiotics ＆ Prebiotics, 2011;6:123-132.

Other Specific Comments

• An executive adviser to the Medical School for academic exchange programs with medical schools or institute overseas.

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